Intragenic regulation of SOCS3 isoforms
نویسندگان
چکیده
منابع مشابه
SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis
SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity, and thereby suppressing cytokine signaling. During embryonic development, SOCS3 is highly expressed in erythroid lineage cells and is Epo independent. Transgene-mediated expression blocks fetal erythropoiesis, resulting in embryonic lethality. SOCS3 deletion results in ...
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متن کاملSocs3
SOCS3 is an inducible negative feedback inhibitor of cytokine signaling. Conditional deletion of SOCS3 in mice using the Cre-lox system has now been applied to a range of cell types in the steady-state and under inflammatory, pathogenic, or tumorigenic stress, with the resulting phenotypes demonstrating the effects of SOCS3 in physiological and disease contexts. Together with recent structural ...
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ژورنال
عنوان ژورنال: Cell Communication and Signaling
سال: 2019
ISSN: 1478-811X
DOI: 10.1186/s12964-019-0379-6